Malvern PA – September 24, 2018. A new cell based profiling service for drug discovery announced by Reaction Biology Corporation (RBC), a premier provider of drug discovery services, and Promega Corporation, a worldwide leader in the supply of life science products, will allow more researchers to better prioritize compounds earlier.
Based on Promega NanoBRETTM technology, the service measures direct target engagement of more than 50 kinases in live cells without disruption of cellular membrane integrity, and will be expanded to cover more than 200 kinases in the future.
“Our customers have been looking for a cell based service to confirm the biochemical assay data we provide,” says Haiching Ma, RBC’s Chief Science Officer. “Finally, with the NanoBRETTM service, they can look at highly relevant cell-based results. The Promega assay is unique in cell-based discovery.”
NanoBRETTM target engagement assays are still available as kits but RBC is the first provider to create an entire panel as a service, allowing more researchers to access the technology.
“Biochemical kinase assays are a piece of the puzzle, but don’t tell the whole story,” says Promega Senior Research Scientist Matt Robers. “By incorporating cellular assays at an earlier stage, researchers can get a better understanding of the impacts of live-cell physiology on the potency and selectivity of their compound. This could save development time and advance chemical matter that has a better chance of having cellular efficacy. Researchers have been seeking these more kinase-specific cell-based assays at service providers, and RBC’s assay optimization expertise and excellent reputation as a service provider make them the logical choice.”
Promega and RBC will launch the new service at the Discovery On Target conference in Boston, September 25-28. Service inquiries can be directed to: NanoBRET@reactionbiology.com.
About RBC: Reaction Biology is a leader in early stage drug discovery services, with over 1,100 clients worldwide and a suite of 2000+ biochemical, cell based, and biophysical assays. The company is the leading provider of kinase based drug discovery services, with 630 kinases covered in the industry’s largest offering of its kind.
About Promega: With a portfolio of more than 4,000 products covering the fields of genomics, protein analysis and expression, cellular analysis, drug discovery and genetic identity, Promega is a global leader in providing innovative solutions and technical support to life scientists in academic, industrial and government settings. Originally, founded in 1978 in Madison, Wisconsin, USA, Promega has branches in 16 countries and more than 50 global distributors serving 100 countries.
Contact: RBC: Haiching Ma, CSO, Haiching.ma@reactionbiology.com, 610-722-0247